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March 1963

Inhibition of Corneal Vascularization by Triethylene Thiophosphoramide (Thio-Tepa)

Author Affiliations

From the Division of Ophthalmology, Department of Surgery, University of Texas Medical Branch. This study was supported by a grant from the Medical Research Foundation of Texas and also an American Medical Research Foundation Grant.

Arch Ophthalmol. 1963;69(3):330-334. doi:10.1001/archopht.1963.00960040336015

An important cause of poor results in corneal transplant surgery is vascularization of the corneal graft. A study has been made of the effect of triethylene thiophosphoramide (Thio-Tepa, Lederele Laboratories) on the growth of new vessels into the corneal graft of rabbits.

In the normal state, the cornea is a transparent, avascular structure. Many pathological conditions of the cornea are accompanied by vascularization, and the prognosis for a clear, avascular graft in these cases is very poor. Even in opaque corneas free of vessels prior to transplantation, the invasion of the graft by new vessels is observed with disappointing frequency. At the present time the most effective therapeutic tool in this condition is β-radiation. Prevention of vascularization of the donor graft with drugs would be a welcome advancement in corneal transplant surgery.

Thio-Tepa is an active antimitotic agent and is related chemically and pharmacologically to the nitrogen mustard compounds. It

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