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March 1963

Homoimmune Uveitis in the Guinea Pig: V. The Effect of Adrenal Corticosteroid

Author Affiliations

San Francisco
Special Fellow, United States Public Health Service (Dr. Aronson).; From the Department of Ophthalmology and the Francis I. Proctor Foundation for Research in Ophthalmology, University of California School of Medicine.

Arch Ophthalmol. 1963;69(3):379-388. doi:10.1001/archopht.1963.00960040385021

Introduction  The beneficial effect of adrenocorticotropin and adrenal corticosteroids on human uveitis is well known.1,2 They also are effective in the treatment of sympathetic ophthalmia which is a possible autoimmune uveal inflammation.3 The severity of inflammation has been well controlled in exogenous experimental uveitis.4,5 Guinea pig homoimmune uveitis serves as an experimental model to evaluate the efficacy of adrenal corticosteroid therapy. Suppression of the inflammation in this type of uveitis may be due to either a nonspecific anti-inflammatory effect, or to a specific inhibition of the reaction caused by the antigen-antibody combination.In the earlier papers of this series the occurrence, clinical characteristics, and histopathologic characteristics of homoimmune uveitis have been discussed.6-8 The clinical observations of Part II and histopathologic observations of Part III serve as control observations for these experiments.


Pigmented Guinea Pig Uveal Antigen.  —This was prepared by mixing uveal tracts with complete

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