The main causes of retinal detachment are degeneration of the retina and degeneration of the vitreous. These degenerative conditions of the retina and vitreous may be the result of myopia, which is the most common cause, or of senescence. Vascular disease also can cause retinal or vitreous degeneration, and some cases of retinal degeneration are idiopathic in nature.
It has been well demonstrated, however, that retinal detachment or at least a predisposition to retinal detachment can be hereditary. Nordlöw1 observed retinal detachment with disinsertion in monozygotic twins who were high myopes. Fransçois2 has observed discordance in a pair of dizygotic male twins. There have been several families having retinal detachment associated with high myopia reported in the literature, and there have been several pedigrees of retinal detachment without myopia. In addition, several pedigrees of retinal detachment due to congenital cystic degeneration of the retina or retinoschisis of the
FREDERICK GILLESPIE, BENITO COVELLI. Hereditary High Myopia With Retinal DetachmentA Family Study. Arch Ophthalmol. 1963;69(6):733–736. doi:10.1001/archopht.1963.00960040739010