The following report describes a patient who developed a melanoma of the choroid in an eye associated with nevus of Ota. Except for one patient in 1860, no other examples of an ocular malignancy occurring with nevus of Ota were found in the literature.
Nevus of Ota is seen as a hyperpigmented area involving the eyelids, frequently the adjacent skin, and usually the eyeball itself. This lesion was originally termed nevus fuscocaeruleus ophthalmomaxillaris and is also frequently referred to as oculodermal melanocytosis. The "nevus" is composed of melanocytes which are identical in appearance and histochemical reaction to those found in the uveal tract.1 It is also closely related to the Mongolian spot, the blue nevus, and certain cases of melanosis oculi.
Nevus of Ota is common among Oriental people, over 400 reports having appeared in the Japanese literature. In none of these, however, has associated ocular malignancy been described.
ALBERT DM, SCHEIE HG. Nevus of Ota With Malignant Melanoma of the Choroid: Report of a Case. Arch Ophthalmol. 1963;69(6):774–777. doi:10.1001/archopht.1963.00960040780019
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