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June 1963

Experimental Aqueous Perfusion in Enucleated Human Eyes

Author Affiliations

From the Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, and Harvard University Medical School.

Arch Ophthalmol. 1963;69(6):783-801. doi:10.1001/archopht.1963.00960040789022

Aqueous perfusion is a convenient and direct means for quantitative evaluation of facility of aqueous outflow (C) in enucleated eyes. The C value is obtained by simple calculation from the rate of injection (F) of saline solution and from the steady state pressure (P) induced in the eye. (Under steady state conditions of equal rate of flow in and out, the relationship at moderate pressures can be expressed as F/P = C.) This is the common basis for evaluation of C by several procedures which differ only in technical details of measurement of flow rate and pressure. (More complex considerations are involved when aqueous perfusion of the eye is applied in vivo or in study of elastic properties of the eye. These are beyond the scope of the present article.)

In study of the mechanics of the outflow channels, good use has been made of aqueous perfusion. Applied to animal eyes,

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