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July 1963

Plasma Cells and Gamma-Globulin in Trabecular Meshwork of Eyes with Primary Open-Angle Glaucoma

Author Affiliations

St. Louis
From the Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine, and the Department of Ophthalmology, University of Freiburg im Breisgau, Germany, Director: Prof. Dr. W. Wegner.

Arch Ophthalmol. 1963;70(1):38-41. doi:10.1001/archopht.1963.00960050040009

Histologic sections of the trabecular meshwork of eyes with primary open-angle glaucoma have been found to stain for γ-globulin.1 Plasma cells were also found in the trabecular meshwork of such glaucomatous eyes. An independent careful study of trephine buttons from glaucomatous eyes revealed similar cells.2

This paper reports on the incidence both of γ-globulin and of plasma cells in a larger series of trephine buttons and eyes from patients with primary chronic open-angle glaucoma.

Material and Methods  Fifty-two trephine buttons* from patients with chronic simple open-angle glaucoma were fixed in neutral formalin or Stieve's solution, embedded in paraffin and sectioned. In addition 28 enucleated or autopsy eyes* with proved chronic simple open-angle glaucoma and 65 routine autopsy eyes were available for study. All specimens included in this study were from patients with bilateral glaucoma and no evidence whatsoever of secondary glaucoma or complicating factors (prior cataract or glaucoma

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