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December 1963

Amphetamine, Barbiturates, and Accommodation-Convergence

Author Affiliations

Berkeley, Calif
From the School of Optometry, University of California.; Work done in part while I was associated with the Columbus Psychiatric Institute, The Ohio State University Health Center, Columbus.

Arch Ophthalmol. 1963;70(6):830-836. doi:10.1001/archopht.1963.00960050832019

It has been demonstrated that barbiturates selectively influence eye movement responses in man. They interfere with normal convergence responses1 and abolish the smooth tracking movements.2 The latter effect is closely associated with the well-known phenomenon of barbiturate nystagmus.3 Accommodation of the eye for near targets seems unaffected by barbiturates.1

Since there is a well-known accommodation-convergence synkinesis,4 thought by many to be an invariable characteristic of an individual, it is of interest to describe the changes in the synkinesis during barbiturate intoxication. The possibility that amphetamine might produce changes in the opposite direction was also investigated in the hope that an indication might be had of the neural level at which these influences operate.

Materials and Methods  Experimental subjects were several normal male students in their early twenties, with no demonstrable intra- or extraocular muscle abnormality, and with no history involving excessive use of any pharmacologic

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