Elsewhere in this issue are two reports on the therapy of experimental ocular toxoplasmosis in the rabbit and guinea pig with pyrimethamine (Daraprim), sulfadiazene, spiramycin, diaminodiphenylsulfone, and two dihydrotriazenes, D63 D110 HCl. The trizaenes had only a limited trial, only a small amount of D63 HCl being available, but suppressed the uveitis for six days. After discontinuing therapy an exacerbation occurred. Both drugs were quite toxic. Diaminodiphenylsulfone was effective in suppressing the uevitis, in a dose of 25 mg/kg, when started on the day of infection. Slightly larger doses, started after the day of inoculation were less suppressive, but improved the outlook.
In general these two reports support the study of Eyles and Coleman1 and Garin and Eyles2 in experimental murine systemic toxoplasmosis, and show that sulfadiazene, pyrimethamine, a combination of sulfadiazene and pyrimethamine, spiramycin, and a combination of pyrimethamine and spiramycin are effective in the control of
H. MJ. Chemotherapy of Toxoplasmic Infections. Arch Ophthalmol. 1964;71(1):1–3. doi:10.1001/archopht.1964.00970010017002
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