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February 1964

The Pathology of Chloroquine Retinopathy

Author Affiliations

Bethesda, Md; Cincinnati, Ohio
From the Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, National Institutes of Health, United States Public Health Service, Department of Health, Education and Welfare, Bethesda (Dr. Bernstein) and the Departments of Ophthalmology, Pathology, and Dermatology, University of Cincinnati, College of Medicine, Cincinnati (Dr. Ginsberg).

Arch Ophthalmol. 1964;71(2):238-245. doi:10.1001/archopht.1964.00970010254019

The clinical manifestations of chloroquine retinopathy have been well documented1 since Hobbs2 called our attention to this entity in 1959. To date, there have been approximately 50 cases reported in the world literature. Chloroquine retinopathy has not been produced in experimental animals, and the ocular pathology in humans has never been described. Thus, the nature and exact location of the pathology are still unknown.

In 1957, Cambiaggi3 reported a case of an unusual macular lesion which was not recognized as due to chloroquine retinopathy at that time. This patient died the following year from systemic lupus erythematosus, and pathologic examination of the eyes was performed. A brief and nonspecific reference to this examination was made by Rebello.4

Recent re-examination of the ocular pathology in this patient has shown that the changes present are compatible with a primary retinopathy and correlate, to a large degree, with the

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