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March 1964

Specific Ocular Uveal Lesions in Patients With Evidence of Histoplasmosis

Author Affiliations

Assistant Professor of Medicine, Assistant Professor of Pediatrics, The Johns Hopkins Medical School; physician and pediatrician, The Johns Hopkins Hospital (Dr. Van Metre); Professor of Ophthalmology and Director of the Department of Ophthalmology, The Johns Hopkins Medical School; Ophthalmologist-in-Chief, The Johns Hopkins Hospital (Dr. Maumenee).; From the Division of Allergy and Infectious Disease of the Department of Medicine and the Department of Ophthalmology, The Johns Hopkins Hospital and Medical School.

Arch Ophthalmol. 1964;71(3):314-324. doi:10.1001/archopht.1964.00970010330006

Information about the causes of endogenous uveal tract infection has been derived from a variety of sources. Microscopic examination and/or culture of infected uveal tissue obtained from enucleated eyes has revealed that potentially pathogenic organisms may be demonstrated in the lesions. The following have been so demonstrated, each in at least one case in which it was presumed to be the cause of the uveitis.

  • Bacteria

    • Mycobacterium tuberculosis1

    • Mycobacterium leprae2

    • Treponema pallidum3

    • Actinomyces4

  • Protozoans

    • Toxoplasma gondi5-8

  • Fungi

    • Aspergillus9

    • Blastomyces10

    • Coccidioides immitis11

    • Cryptococcus12

    • Mucor13

  • Helminths

    • Nematodes

      • Filaria16

      • Onchocerca14

      • Toxocara larvae15

    • Cestodes

      • Cysticercus12,16

      • Echinococcus16

  • Viruses

    • Cytomegalic inclusion disease17

  • Insects

    • Fly larvae 16

In rare instances, pathogenic organisms have been isolated from fluid aspirated from the infected eye. Leptospira,18Toxoplasma,20 herpes simplex virus,21 and cytomegalic inclusion virus19 have been cultured from anterior chamber fluid, and Toxoplasma from subretinal fluid20 obtained from patients with uveitis.

The frequent occurrence of

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