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To the Editor:
—In the Clinicopathological Exercise (case 53, 1963) in the August 15 issue of the Journal a physician asked, "I was wondering if it is possible for a woman to have two healthy children and then give birth to one with congenital toxoplasmosis, or whether, if that diagnosis is correct in this case, the previous children were also affected."Dr. Castleman replied: "I don't believe that toxoplasmosis in siblings has ever been reported. Toxoplasmosis is a disease acquired by the mother during the pregnancy rather than a hereditary defect."It is of interest that in Obstetrics and Gynecology (21:318-329 [March] 1963) Dr. Heinrich Langer reported repeated congenital infection in siblings with Toxoplasma gondii. In one case Toxoplasma was isolated from the brains of two successive stillborn infants of the same mother. In another case Toxoplasma was isolated from the menstrual blood of each period until the next conception
Hinrichs WL. CONGENITAL TOXOPLASMOSIS IN SIBLINGS. Arch Ophthalmol. 1964;71(3):449. doi:https://doi.org/10.1001/archopht.1964.00970010465030
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