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April 1964

Band Keratopathy and Conjunctival Calcification in Hypophosphatasia

Author Affiliations

New York
From the Department of Surgery (Ophthalmology), The New York Hospital-Cornell Medical Center, New York.; Present addresses: Howe Laboratory of Ophthalmology, Harvard University Medical School, Boston (Dr. Lessell); Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, Miami (Dr. Norton).

Arch Ophthalmol. 1964;71(4):497-499. doi:10.1001/archopht.1964.00970010513011

Band keratopathy and conjunctival calcification are recognized ocular manifestations of hypercalcemia.1-3 Their occurrence has been recorded in Boeck's sarcoid, hypervitaminosis D, hyperparathyroidism, carcinoma of the parathyroid, the milk-alkali syndrome, chronic immobilization, and renal insufficiency. The purpose of this communication is to document the association of the ocular signs of hypercalcemia with a rare, inborn-error of metabolism, hypophosphatasia.

Report of Case*  A 17-week-old, white male was admitted to the pediatric service of the New York Hospital on Sept 13, 1957, because of vomiting and failure to gain weight. He was the product of a normal, spontaneous delivery following an uncomplicated, full-term pregnancy. The patient weighed 9 lb 12 oz (4,423 gm) and was 22 inches long at birth. Head circumference was 15.25 inches. Development was unremarkable until the seventh week when excessive regurgitation of feedings was noted. He also appeared unusually irritable. Despite alterations in formula and the use of

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