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April 1964

Biochemical Studies of Subretinal Fluid: III. Ascorbic Acid of Subretinal Fluid in Patients With Retinal Detachments

Author Affiliations

From the Department of Ophthalmology, Indiana University School of Medicine.

Arch Ophthalmol. 1964;71(4):556-557. doi:10.1001/archopht.1964.00970010572024

The purpose of this paper is to report on the ascorbic acid content of subretinal fluid (SRF) in 75 cases of idiopathic retinal detachment, relating the findings to certain clinical data.

Heath et al1 (27 cases) reported that the mean "total" ascorbic acid * content of SRF from eyes in which no retinal break could be found was significantly lower than in those having a visible retinal hole. In all strictly idiopathic cases, the ascorbic acid content of the SRF was found to be from 2-24 times that of the blood.

De Vincentiis3 determined the "true" ascorbic acid † content of SRF in 12 cases and found it to be from 3 to 6.5 times the plasma level. In three cases, the SRF level of "true" ascorbic acid was from 50% to 75% of the aqueous level.

Materials and Methods  The subretinal fluid from 75 cases was collected, tested

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