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May 1964

Retinal Detachment in Adult Dogs Resulting From Oxygen Toxicity

Author Affiliations

From the Departments of Experimental Surgery and Ophthalmology, Clinical Sciences Division, USAF School of Aerospace Medicine, Aerospace Medical Division (AFSC), Brooks Air Force Base, Texas (Capt Beehler, Capt Newton, Lt Col Culver); from the Ophthalmic Pathology Section, Armed Forces Institute of Pathology, Washington, DC (Maj Tredici).; Present address: Box 281, The Bowman Gray School of Medicine, Winston-Salem, NC (Capt Beehler).

Arch Ophthalmol. 1964;71(5):665-670. doi:10.1001/archopht.1964.00970010681013

Introduction  Recent experiments have indicated that high oxygen concentrations have a toxic effect on the adult animal eye. In view of the ever increasing interest in the use of oxygen at high partial pressures, for therapy and for environmental research, the limits of oxygen toxicity in regard to the visual system should be clearly defined.This study was initiated to determine the effects of chronic exposure to high oxygen tensions on the visual mechanisms of the adult animal.

Method  Adult mongrel dogs were exposed to high oxygen environments, ranging from 90% to 100% (680 to 760 mm Hg) in a sealed chamber. Excess moisture was absorbed with Silica Gel, maintaining the humidity between 40% and 90%. Carbon dioxide, absorbed on barium hydroxide, was held below 0.9% and usually averaged below 0.5%. The chamber was located in an air-conditioned room, so that no additional equipment was necessary to hold the temperature

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