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May 1964

Induced Spasm in the Retinal Arterioles of Cats: II. Influences of Physical Factors and Drugs

Author Affiliations

From the Divisions of Ophthalmology and Neurosurgery, University of Colorado Medical Center.

Arch Ophthalmol. 1964;71(5):706-711. doi:10.1001/archopht.1964.00970010722020

The experimental model described in our previous communication1 has been used to study factors which might be concerned with the induction of retinal arteriolar spasm, and to evaluate measures which might be used to prevent or relieve the spasm. Air embolism, changes in intravascular pressure, and surgical manipulation of the globe have been theorized to effect ocular damage by induction of vascular spasm. The influences of these conditions on exposed retinal arterioles have been observed. In addition, certain effects of selected drugs on arteriolar spasm have been studied.

In vivo observations of the intraocular vessels have been made by numerous investigators with techniques of ophthalmoscopy, biomicroscopy, retinal photography, and ophthalmodynamometry. Other in vivo methods used to study intraocular vessels are color television ophthalmoscopy,2 cinematography,3 scleral window with microscopic examination of the choroidal vessels,4,5 radioactive phosphorus uptake studies,6,7 transscleral window with pupillary illumination and microscopic examination