Cryoglobulins are groups of cold-precipitable proteins greatly resembling normal γ-globulin,1 and their most striking characteristic is their ability to precipitate when exposed to a lowered temperature. An essential part of the phenomenon relates to the precipitate returning to solution when the temperature is raised to 37 C. The most prominent symptom noted in this disease is a particular sensitivity to lowered temperature with oronasal bleeding a common finding.2 Physical findings include weight loss, pallor, petechiae with purpura, mottling and occasional ulceration of the lower extremity. The ocular findings include slowing and stasis of blood flow with marked erythrocytic aggregations in the vessels of the bulbar conjunctiva.3 Ophthalmoscopic study has demonstrated dilated retinal veins with slowing and segmentation as well as occasional retinal hemorrhages and exudates.4In 1957 Harders5 reported observations on conjunctival blood flow in a patient with Waldenström's macroglobulinemia who in addition
FINK AI, TSUNEMATSU M, KAPLAN D. Conjunctival Blood Flow in Cryoglobulinemia. Arch Ophthalmol. 1964;71(6):787–792. doi:10.1001/archopht.1964.00970010803003
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