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July 1964

Retinal Involvement in Adult Cytomegalic Inclusion Disease

Author Affiliations

St. Louis
Present address until January, 1965: Ophthalmic Pathology Branch, Armed Forces Institute of Pathology, Washington, DC 20025.; From the Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine.

Arch Ophthalmol. 1964;72(1):44-49. doi:10.1001/archopht.1964.00970020046011

In recent years, increasing attention has been given to the clinical entity known as cytomegalic inclusion disease or generalized salivary gland virus disease. This multisystem viral disease is characterized histologically by the peculiar giant cells with intranuclear and cytoplasmic inclusions.1 The disease is primarily of interest to the pediatrician since it occurs most commonly in the newborn and is manifested by prematurity, jaundice, thrombocytopenia, anemia, hepatosplenomegaly, and neurological involvement.2 In addition, these affected infants frequently have chorioretinitis, and the disease therefore becomes of particular interest to the ophthalmologist as well.3-6 Because of the chorioretinal findings and the frequent finding of intracranial calcification, clinical differentiation from toxoplasmosis is difficult.3 Besides the generalized form in the newborn, it has been reported that the inclusions occur in the salivary glands of 8% to 32% of infants and young children who die from various causes.7

The disease in the

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