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August 1964

Topical Corticosteroids and Aqueous Humor Dynamics

Author Affiliations

Bethesda, Md
From the Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare.

Arch Ophthalmol. 1964;72(2):189-197. doi:10.1001/archopht.1964.00970020189009

Locally and systemically administered corticosteroids have been implicated as a causative factor in the elevation of intraocular pressure.1-7 Recently, the extensive studies of Armaly8,9 and Becker10 have clearly documented the relationship of corticosteroid medication and the rise of intraocular pressure. The present investigation is a further attempt to elucidate this steroid-induced oculotensive phenomenon.

Material and Methods  Three groups of subjects were studied in the following manner.

Group A. Open-Angle Glaucoma Patients.  —The group comprised 11 patients. Eight were receiving 2% l -epinephrine hydrochloride and three were using pilocarpine. The patients were instructed to use 0.1% dexamethasone topically, one drop four times a day in one eye, while continuing their glaucoma medications in both eyes. Intraocular pressure measurements with the Goldmann Applanation Tonometer and the Mueller Electronic Tonometer were performed along with tonography at varying intervals, usually weekly. If the ocular pressure rose to 28 mm Hg by