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August 1964

Ophthalmological Use of Mannitol

Author Affiliations

From the Department of Ophthalmology, University of Tennessee College of Medicine; City of Memphis Hospitals; and the Memphis Eye, Ear, Nose, and Throat Hospital.

Arch Ophthalmol. 1964;72(2):219-224. doi:10.1001/archopht.1964.00970020219013

Introduction  Mannitol is the reduced form of the sixcarbon sugar mannose, and is essentially unmetabolized, limited to the extracellular space, freely filtered by the glomeruli, and neither reabsorbed nor actively excreted by the renal tubules1,7,9,10; thus it has been useful as an osmotic diuretic as well as in the measurement of glomerular filtration rate.3,7 It has recently been used as a hypertonic intravenous solution for the osmotic reduction of intraocular pressure.1,11,12 It is chemically stable and can be stored in solution at room temperature ready for use.Its ocular hypotensive effect has been used in many ophthalmic conditions, such as acute angle-closure glaucoma, chronic open-angle glaucoma, many forms of secondary glaucoma, and in glaucomatous and nonglaucomatous patients prior to intraocular surgery in order that the eye will be normotensive or even hypotensive at the time of surgery.1,11,12 The hypotensive effect (on cerebrospinal fluid pressure) has been