The effects of corticosteroids on ocular tension have received considerable attention of late, since exogenous steroids have been reported to produce ocular tension increases. Certain topical glucocorticoids, after varying periods of time, have caused ocular tension rises in both glaucomatous and normal individuals.1-3 Minimal ocular tension increases have also been noted in some patients after long-term usage of systemic glucocorticoids.4 The tension elevations after both topical and systemic steroids were secondary to reduced facility of outflow.It is difficult to be certain of the metabolic basis for the ocular tension effects of these steroids. The uncertainty is due to the multiple metabolic effects (eg, anti-inflammatory, glycogenic, catabolic, osteoporotic, and electrolytic) of glucocorticoids. The only adrenal cortical hormones available with predominantly one mode of action (electrolytic) are the mineralocorticoids. Any ocular tension effects of these hormones might elucidate similar effects of other adrenal hormones.This study was undertaken
FRENKEL M, KRILL AE. Effects of Two Mineralocorticoids on Ocular Tension. Arch Ophthalmol. 1964;72(3):315–318. doi:10.1001/archopht.1964.00970020315004
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