The problem of early detection of intraocular tumors is a very real one and needs no belaboring for the ophthalmologist. Since Ehrlich propounded the concept of specific chemotherapy, researchers have looked for tissue-specific drugs. The possibility of tumor detection with the help of substances that localize in specific tissues has been explored with some diligence in the past, although with disappointing results.
An attempt to utilize radioactive tracers for diagnosis of ocular tumors was reported by Thomas et al1 more than ten years ago. The method was based on external counting of the suspected eye after administration of P32 and depended upon greater incorporation of isotope in the phosphorylated compounds of rapidly growing tumor tissue than in normal ocular tissue. Despite early enthusiasm, this technique has added little to the diagnosis of ocular tumors, particularly those of the posterior segment.
If a compound could be found that would
POTTS AM. Tracer Studies on a Transplantable Hamster Melanoma. Arch Ophthalmol. 1964;72(3):359–364. doi:https://doi.org/10.1001/archopht.1964.00970020359014
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: