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If we may accept a generalization based on the files of the Armed Forces Institute of Pathology, one out of every five eyes removed with a clinical diagnosis of melanoma of the choroid turns out to have some other lesion instead. In an article published elsewhere in this issue, Ferry reports 100 eyes enucleated for the erroneous clinical diagnosis of melanoma. In all these eyes the media had been sufficiently clear to permit visualization of the lesion. Of the 100 eyes, two thirds had retinal lesions, one fourth had other choroidal or ciliary body lesions, and the remainder had lesions of the vitreous body or optic nerve head. The most common retinal lesions mistakenly diagnosed as malignant melanoma were retinal detachment, macular degeneration of the Kuhnt-Junius type, chorioretinitis, retinoschisis, and discoid hypertrophy of the pigment epithelium. Lesions of the ciliary body and choroid that led to enucleation with the mistaken
C. DG. Melanoma or No. Arch Ophthalmol. 1964;72(4):451–452. doi:https://doi.org/10.1001/archopht.1964.00970020451001
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