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October 1964

Leukemic Miliary Nodules in the Retina

Author Affiliations

Howe Laboratory of Ophthalmology, Harvard University Medical School, Massachusetts Eye and Ear Infirmary.

Arch Ophthalmol. 1964;72(4):494-497. doi:10.1001/archopht.1964.00970020494010

Leukemia is frequently manifest in ocular tissue by retinal hemorrhages, leukemic cells in blood vessels, and occasionally by diffuse infiltration of the choroid. Proliferation of leukemic cells in the retina has been rarely observed. The present report concerns tumor proliferation in the retinas of a patient with chronic myelogenic leukemia.

Report of Case  The patient (No. 111-29-48, Howe Laboratory 63-611) was a 60-year-old mechanic who had observed a mass in the left upper quadrant of his abdomen five years previously. Hematologic examination revealed chronic myelogenic leukemia with a white blood cell count of 23,000. Splenectomy and busulfan (Myleran) administration controlled the white cell count, and the patient was asymptomatic until two months prior to death. His white cell count then rose to 57,000, and he was readmitted to the hospital. Despite repeated transfusions he became cachectic and died. The eyes were removed three hours post mortem.On opening the

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