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October 1964

Allergic Response of Retinal Vessel 6: After Intravitreal Foreign Protein

Author Affiliations

Wills Eye Hospital.

Arch Ophthalmol. 1964;72(4):513-520. doi:10.1001/archopht.1964.00970020513015

Introduction  Two types of cells have been identified on the retinal capillaries of humans1-4 and animals.1,5,6 One type is the endothelial cell which is the main component of the capillaries. A second type of cell has been called a mural cell by Kuwabara et al.7 It also has been called an intramural pericyte, a pericyte, or an undifferentiated cell. The function and characteristics of these cells are not well established. Kuwabara and Cogan have assumed that the mural cells play a significant role in the retinal capillary function.9 They suggest that inhibition of neovascularization may be one function of the mural cell, also that these cells may participate in the control of capillary tone.8The reaction of the endothelial and mural cells of the retinal capillaries and the other vascular structures to an experimentally produced allergic condition in the animal eye was investigated using the