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November 1964

Retinal Dysplasia

Author Affiliations

Los Angeles
From the Estelle Doheny Eye Foundation and the University of Southern California, School of Medicine.

Arch Ophthalmol. 1964;72(5):637-641. doi:10.1001/archopht.1964.00970020637010

The purpose of this report is to present a characteristic case of retinal dysplasia and by demonstrating the pathology to emphasize its differentiation from the other conditions which produce leukocoria, particularly retinoblastoma and retrolental fibroplasia.

The term "retinal dysplasia" was coined by Reese and Blodi to apply to a group of cases showing dysplastic differentiation of the sensory retina in association with other nonocular abnormalities.

Report of Case 

Clinical Summary.  —The patient, a white male infant, 4 lb 12 oz (2.2 kg), was born spontaneously at approximately term. He was cyanotic with a feeble cry and ceased to breathe 25 minutes after birth despite placement in an incubator and administration of intravenous fluids. The mother was a 38-year-old gravida VII para VI with a normal prenatal history. Rh factor was positive and serologic test for syphilis negative.

Autopsy Findings.  —The palpebral fissures were slit-like and the globes microphthalmic. The nose

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