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December 1964

The Effect of Topical Corticosteroids in Secondary Glaucomas

Author Affiliations

St. Louis, Mo
From the Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine.

Arch Ophthalmol. 1964;72(6):769-771. doi:10.1001/archopht.1964.00970020771005

Elevations of intraocular pressure and decreases in outflow facility have been reported after the topical administration of glucocorticoids.1-6 Marked changes have been observed in patients with proved primary openangle glaucoma, but remarkable elevations of pressure have also been noted in the families of glaucoma patients as well as in some apparently "normal" individuals. The working hypothesis was formulated that the intraocular response to topical corticosteroids was genetically determined and transmitted as a monogenic dominant.7 An alternative suggestion was that the glaucomatous eye, with its damaged outflow channels, responded more dramatically than the normal eye to the effects of steroids and related pharmacologic agents.5 One method for testing these alternate hypotheses would be to evaluate the effects of topical corticosteroids on eyes with secondary glaucomas. Since the marked response occurred in almost all eyes with primary open-angle glaucoma but only in about 35% of "normal" volunteers, such a

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