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December 1964

Intraocular Pressure and Visual Fields: Effects of Corticosteroids

Author Affiliations

St. Louis
From the Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine.

Arch Ophthalmol. 1964;72(6):772-782. doi:10.1001/archopht.1964.00970020774006

Introduction  Patients with glaucoma who have progressive loss of visual field usually demonstrate elevations of intraocular pressure. The pressure susceptibility to the loss of field varies greatly from individual to individual. In some instances it may be related to the level of systemic blood pressure.1,2 Attempts have been made to produce rapid changes in intraocular pressure by pressure or suction applied to the globe and to estimate the pressure level at which field defects occur.2-5 Such approaches have stimulated considerable interest in the posterior segment aspects of glaucoma but have been difficult to standardize or duplicate because of ocular distention, vascular effects, and the lack of steady state conditions.Recently it has been demonstrated that topical corticosteroids decrease outflow facility and elevate intraocular pressure when applied to the eyes of patients with primary open-angle glaucoma, of glaucoma suspects, and of some volunteers.6 The pressure can be raised

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