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January 1965

Ophthalmic Ointment Bases in the Anterior Chamber: Clinical and Experimental Observations

Author Affiliations

From the Department of Ophthalmology, Hospital of the University of Pennsylvania, Philadelphia General Hospital, Veterans Administration Hospital, and the Children's Hospital of Philadelphia.

Arch Ophthalmol. 1965;73(1):36-42. doi:10.1001/archopht.1965.00970030038009

Introduction  This paper presents clinical and experimental observations on the effects of ointment bases and oily vehicles in the anterior chamber of the eye. Our interest in this subject was stimulated by clinical experience with two eyes. The first had peanut oil instilled, at the time of surgery, into the anterior chamber where it has persisted for 18 years. Follow-up examinations have been made at yearly intervals. The second eye contained atropine ointment, which entered the anterior chamber following instillation into the conjunctival cul-de-sac upon completion of keratoplasty. It has been observed for three years. Only a few reports on the effect of oily substances and ointment bases in the anterior chamber have appeared in the literature1-7 (the Table). Such materials apparently persist unabsorbed, but statements as to their effects have been contradictory.We, therefore, performed experiments injecting commonly used ophthalmic ointment bases and liquid oily vehicles into the