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January 1965

Experimental Induction of Disciform Keratitis

Author Affiliations

Gainesville, Fla
Division of Ophthalmology, University of Florida College of Medicine.

Arch Ophthalmol. 1965;73(1):112-114. doi:10.1001/archopht.1965.00970030114023

Disciform keratitis is a term introduced by Fuchs in 1901 to describe a central corneal opacification that is seen most often as a late complication of herpes simplex keratitis.1 Clinically, two kinds of stromal disease may occur after herpes simplex infection. In one type, dense, white, cheesy opacities which are generally eccentric occur. The pathogenesis of these lesions appears to be different from those of the typical disciform lesion. The disciform lesion is characterized by a round patch of corneal edema which is generally central and is typically surrounded by normal cornea. In the involved area of cornea, there are folds in Descemet's membrane, swelling of the stroma, and often epithelial bullae. In the early stages the disciform lesion is reversible, but as the edema persists, corneal scarring and permanent opacities often develop. Although the exact incidence of disciform keratitis following corneal herpes simplex is not known, in 1956,