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January 1965


Author Affiliations

389 Loudonville Rd Loudonville, NY 100

Arch Ophthalmol. 1965;73(1):147. doi:10.1001/archopht.1965.00970030149032

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To the Editor:  The article entitled, "Treatment of Trichinosis" (Arch Ophthal 71:359-363, 1964), by Spaeth et al, is most interesting. In view of the fact that they claim this to be the first human case treated, a correction of dosage becomes important for the guidance of those who may wish to use thiabendazole in the treatment of trichinosis and possibly other larval helminthic infestations (cutaneous and visceral larva migrans).The regimen of therapy used by Spaeth et al was 0.5 gm every 12 hours for seven consecutive days. On page 362 they stated that the drug "was prescribed in a dose of 1,000 mg a day (60 mg/kg/day), divided into two equal doses, for a period of seven days." Their patient was a 22-year-old, well-developed female student of Lithuanian extraction. Although her actual body weight was not given, she probably weighed 50 or 60 kg, in which case the daily

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