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February 1965

Radioactive Idoxuridine Administered Into the Conjunctival Sac of the Rabbit: A Study of the Metabolism and Tissue Distribution

Author Affiliations

New Haven, Conn
Department of Pharmacology and Section of Ophthalmology, Department of Surgery, Yale University School of Medicine.

Arch Ophthalmol. 1965;73(2):248-252. doi:10.1001/archopht.1965.00970030250019

Introduction  Idoxuridine (5-iodo-2′-deoxyuridine, IUDR, IDU)1 inhibits the formation and utilization of phosphorylated derivatives of thymidine, as well as the biosynthesis of DNA-thymidylic acid in various murine and human neoplastic tissues.2 The nucleoside is incorporated extensively into the DNA-polymer, in lieu of the natural component, thymidine, of mammalian cells, bacteria, bacteriophage and, more recently, animal viruses3 (see bibliography in reference 4). Although the effectiveness of idoxuridine as an inhibitor of the growth of neoplasms is still under investigation,5 its status as an antiviral agent in the treatment of some established DNA-viral infections in animals, as well as in man, has been well substantiated.The antiviral activity of idoxuridine was first demonstrated by Herrmann6 and this finding was extended by Kaufman and his associates to the treatment of herpes simplex keratitis in rabbits and man.7 These results in rabbits, although questioned by some,8 for the

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