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March 1965

Eyes With Choroidal Detachments Removed for Suspected Melanoma

Author Affiliations

From the Wilmer Ophthalmological Institute, The Johns Hopkins Hospital, Baltimore.

Arch Ophthalmol. 1965;73(3):320-323. doi:10.1001/archopht.1965.00970030322005

Introduction  The differential diagnosis of malignant melanoma of the choroid can be quite difficult. Despite the advantage gained in recent years by use of the binocular indirect ophthalmoscope, the incidence of false positive and false negative diagnosis in enucleated eyes is about 10%.1-5 The failure to diagnose a malignant melanoma in an eye removed for other reasons is frequently the result of impaired ocular media. However, the mistaken diagnosis of melanoma when it is not present is usually the result of incorrect interpretation of the clinical picture, particularly the ophthalmoscopic picture. This problem has been extensively covered in the literature over the past ten years.2-9 Knapp10 first reported the enucleation of an eye containing a choroidal detachment following cataract extraction which had been clinically diagnosed as a sarcoma. This situation has recurred intermittently over the past 100 years.11The following two case reports describe a condition

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