The demonstration by Wilder1 of nematode larvae in 24 of 46 eyes enucleated following a clinical diagnosis of retinoblastoma, pseudoglioma, Coats' disease, or panophthalmitis and the identification of the nematode in four of these cases as Toxocara canis by Nichols2 emphasized the importance of this parasite in human ocular disease. Ashton3 reported similar findings in a series of four cases with granulomata of the macula and Irvine4 reported one case, thus confirming the work of Wilder. Ashton pointed out that sometimes hundreds of sections of an eye must be examined before the nematode larva is found. Unless a presumptive clinical and serological diagnosis can be made, routine pathologic examination of the enucleated eye may fail to elucidate the diagnosis.
T canis is the roundworm of the dog. Ingested embryonated ova hatch in the dog intestine. The larvae penetrate the intestinal wall and are carried to the
RONALD M. WOOD, ARTHUR C. ELLISON, KATHLEEN C. KELLEY, HERBERT E. KAUFMAN. Antibody to Toxocara Canis in Humans. Arch Ophthalmol. 1965;73(4):482–486. doi:10.1001/archopht.1965.00970030484007