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April 1965

The Action of Angiotensin on Intraocular Pressure

Author Affiliations

Bethesda, Md
From the Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, National Institutes of Health, US Public Health Service, Department of Health, Education and Welfare.

Arch Ophthalmol. 1965;73(4):528-539. doi:10.1001/archopht.1965.00970030530016

Introduction  Current findings strongly suggest that intraocular pressure (IOP) of the cat eye is dependent upon venous pressure2-5,7-10 which in turn can be regulated by changes in resistance of the iris artery and its radial branches.6Acetazolamide has been demonstrated to lower intraocular pressure, at least in part, by its ability to produce a fall in venous pressure2,3 through its constrictive effect of the iris blood vessels.6 Many other agents, even though of diverse origin and activity, which have been shown capable of producing a lowering of IOP in patients with glaucoma, have all been found to have the common effect of producing an increase in resistance in the iris artery.9Recently dilutions of serum were also shown capable of producing increases in resistance of the iris artery. Almost all of this serum vasoconstrictor activity could be ascribed to a substance which had many of

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