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May 1965

Effect of Vasodilator Drugs on the Retinal Blood Flow in Man

Author Affiliations

From the Department of Medicine, Indiana University School of Medicine, Indianapolis.

Arch Ophthalmol. 1965;73(5):640-642. doi:10.1001/archopht.1965.00970030642008

Introduction  The regulation of retinal blood flow and vessel size in man is still imperfectly understood. Numerous drugs have been used in an effort to produce vasodilatation and an increase in blood flow to the retina and choroid. Bettman and Fellows1 have shown in cats that many of the peripheral vasodilator and vasoconstrictor drugs do little to influence the intraocular blood volume. Walsh2 has reviewed some of the attempts to evaluate the effect of drugs. Until recently, such studies in the human have been limited to estimations of caliber changes in the retinal vessels. Changes in the size of the resistance vessels cannot be detected with confidence by present techniques because of the small size of the vessels. It is now possible by means of photographic techniques to measure the retinal venous oxygen saturation.3 Such measurements yield an index of flow change provided retinal metabolism is not

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