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May 1965

Nerve Fibrils in Ovoid Bodies: With Neurofibromatosis of the Choroid

Author Affiliations

Ann Arbor, Mich
From the Departments of Ophthalmology and Pathology of the University of Michigan Medical Center. Supported by The Research to Prevent Blindness, Inc., New York, NY. Presented at the East Central Section of the Association for Research in Ophthalmology, Detroit, 1-3, 1963.

Arch Ophthalmol. 1965;73(5):696-699. doi:10.1001/archopht.1965.00970030698019

Ovoid bodies are a typical histologic detail of choroidal neurofibromatosis. In the literature these bizarre onion-like formations are mentioned in virtually all studies on ocular involvement in neurofibromatosis and much thought has been given to the question whether the ovoid bodies are nerve end formations or not.1-6 The present paper is to present evidence that nerves enter the ovoid bodies and branch in the spaces of their onion-like layers of Schwann cells in a delicate pattern. This very much resembles the arrangement of terminal nerves in human sensory end organs.

Report of Case  This 14-year-old boy was first seen on Sept 8, 1953, in this Eye Clinic by Dr. H. F. Falls. There was a history of right unilateral congenital buphthalmus and facial hyperplasia on the same side. The diagnosis of neurofibromatosis involving the eye had already been made early in his life. Several attempts at ocular surgery to

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