[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
June 1965

Pathogenesis of Rubella Cataract: Gregg's Syndrome

Arch Ophthalmol. 1965;73(6):761-763. doi:10.1001/archopht.1965.00970030763001

During the winter and spring of 1963-1964 the United States experienced one of the largest outbreaks of rubella of the past 20 years. Since rubella is not a nationally reportable disease and because so many infections are atypical or subclinical, no reliable data are available as to the actual number of cases. Nevertheless, it can be safely concluded that thousands of pregnant women were exposed and already our pediatric hospitals are experiencing the sequelae of last year's epidemic.

The concept that an otherwise benign exanthematous disease such as German measles might be a cause of congenital malformations was introduced by the Australian ophthalmologist, Sir Norman Gregg. It was in 1941 that this astute clinician reported the occurrence of a distinctive nuclear cataract in babies born of mothers who had contracted rubella in the early months of pregnancy. His brilliant observations, which included the fact that many of the affected babies