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June 1965

Ocular Penetration of Amphotericin B: A Report of Laboratory Studies and a Case Report of Postsurgical Cephalosporium Endophthalmitis

Author Affiliations

Bethesda, Md
From the Ophthalmology Branch, National Institute of Neurological Diseases and Blindness (Dr. Green), the Laboratory of Clinical Investigations (Dr. Bennett), and the Laboratory of Infectious Diseases (Dr. Goos), National Institute of Allergy and Infectious Diseases, National Institutes of Health, US Public Health Service, Department of Health, Education and Welfare, Bethesda, Md.

Arch Ophthalmol. 1965;73(6):769-775. doi:10.1001/archopht.1965.00970030771004

Introduction  Amphotericin B is well established as a fungistatic agent1 that is effective in the treatment of several systemic mycotic infections.2 Experience with its use in fungus diseases of the eye, though apparently beneficial, has been limited.3-6 Two reports have been found in which amphotericin B was used in the treatment of postoperative mycotic intraocular infections.5,6Whether amphotericin B penetrates the eye is unknown. Previous attempts to demonstrate such penetrations have been unsuccessful,3 and it has been stated that amphotericin B cannot be identified in intraocular fluids following parenteral administration.4Recently a patient with postoperative mycotic endophthalmitis was observed in whom the use of intravenous amphotericin B resulted in a dramatic response with clearing of the infection. The clinical observation prompted laboratory studies of the intraocular penetration of amphotericin B in rabbits under experimental conditions.

Case Report  A 75-year-old white woman was first found

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