The infusion of α-chymotrypsin into the anterior chamber of the eye during cataract surgery has raised important questions on the effect of this proteolytic enzyme on various eye structures. The studies to date have used histological methods to assess the changes and have shown, not surprisingly, that the enzyme can damage tissues of the eye. Thus Maumanee (1960) reported that injection of 15 units (see Schwartz and Schwartz, 1960) of α-chymotrypsin into the vitreous of rabbits produced localized atrophy of the retina with the supporting structures of the retina most affected.Radnót and Pajor (1959) similarly noted damage to the retina of the rabbit although they did not state the dosage or route of administration of the enzyme. In the dog, O'Malley et al (1961) reported that injection of 0.4 cc of 1/5,000 parts of α-chymotrypsin (about 60 units) produced a high incidence of retinal damage. The rods and
HAMASAKI, ELLERMAN N. Abolition of the Electroretinogram: Following Injection of α-Chymotrypsin Into the Vitreous and Anterior Chamber of Monkey. Arch Ophthalmol. 1965;73(6):843–850. doi:https://doi.org/10.1001/archopht.1965.00970030845017
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