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To the Editor:
During a recent clinicopathologic study of eyes which had been enucleated for retinoblastoma, certain observations regarding the efficacy of photocoagulation in the control of malignant ocular tumors were made. Since there are unavoidable delays in the preparation of a manuscript and in its publication, and since the information may be of some import, the findings regarding light coagulation are being sent in the form of this preliminary letter.Sufficient evidence has now been accumulated in the ocular pathology laboratory of this Institute to indicate that repeated and heavy light coagulation of resistant retinoblastoma may be associated with an aggressive replacement of the uveal tract by tumor, and with invasion of the sclera itself. This sequence of events apparently results because of the necrosis which is induced in natural barriers to outward extension of the tumor, namely, Bruch's membrane and sclera.This is not to condemn light coagulation,
Howard GM. SPREAD OF RETINOBLASTOMA BY PHOTOCOAGULATION. Arch Ophthalmol. 1965;73(6):906–907. doi:10.1001/archopht.1965.00970030908028
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