Phenothiazine derivatives have a wide-spread important use as psychotherapeutic agents. The nitrogen in the thiodiphenylamine molecule is the pharmacologically active position. There are three groups of phenothiazine derivatives determined by the substituted side chain. Group I is the dimethyl-aminopropyl of which chlorpromazine (Thorazine) is an example. Group II is the piperazinyl propyl derivative; eg, prochlorperazine (Compazine). Group III is the piperidyl ethyl derivative; eg, thioridazine hydrochloride (Mellaril).The most serious ocular side effect occurring with a phenothiazine derivative administration is a pigmentary retinopathy with visual loss. This complication apparently is limited to piperidyl derivatives such as NP-207 with a narrow therapeutic-toxic range and thioridazine hydrochloride which is claimed to be safe if administered in amounts of less than 800 mg daily.A less serious ocular side effect has been reported recently associated with long-term therapy with chlorpromazine. This complication is a deposit on the anterior lens capsule and the
WETTERHOLM DH, SNOW HL, WINTER FC. A Clinical Study of Pigmentary Change in Cornea and Lens in Chronic Chlorpromazine Therapy. Arch Ophthalmol. 1965;74(1):55–56. doi:10.1001/archopht.1965.00970040057013
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