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July 1965

LSD-25 and Accommodative Convergence Ratios

Author Affiliations

From the United States Army Chemical Research and Development Laboratories, Edgewood Arsenal, Md.

Arch Ophthalmol. 1965;74(1):81-85. doi:10.1001/archopht.1965.00970040083020

Introduction  Experimentation in both human volunteers and laboratory animals with the psychotomimetic drugs, particularly d-lysergic acid diethylamide (LSD-25), in recent years has revealed that in addition to the more prominent and well-described mental changes there are also decided effects on the autonomic nervous system, as manifested most frequently by mydriasis, increased blood pressure, tachycardia, pilo-erection, hyperthermia, and hyperglycemia.1,2 It is generally believed that these peripheral autonomic effects are the result of the central action of LSD-25. Some investigators3 have postulated that the parasympathetic centers are activated by a serotonin system and that the action of LSD-25 is through antagonism to the normal action of serotonin. Others4 have have felt that LSD-25 causes direct stimulation of mesencephalic and diencephalic sympathetic centers. The mechanism of this central action of LSD-25 on the autonomic system, whether by sympathetic stimulation or by parasympathetic inhibition, has yet to be clarified.Although LSD-25