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July 1965

Bacillus Infections of the Cornea

Arch Ophthalmol. 1965;74(1):91-95. doi:10.1001/archopht.1965.00970040093022

Introduction  The pathogenicity of the gram-positive, spore-forming bacilli for the eye was first reported in 1890,1 when these microorganisms were found in the vitreous of eyes enucleated for panophthalmitis. Since then numerous reports have incriminated the gram-positive bacilli as etiological agents in virtually all types of infections of the eye.2-6 The postulates of Koch however could not be fulfilled beyond doubt with the exception of inflammations confined to the vitreous, which could be reproduced readily in experimental animals.7-9In studying the role of pathogens in eye disease one cannot always rely on the postulates of Koch, in order to attribute certain pathogenic characteristics to the parasite. Modern experimental work in virology has shown that some of the organisms have a considerable host specificity. Other factors such as variations in host resistance are also an obstacle in the fulfillment of the postulates. On the other hand the isolation

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