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Otto-Erich Lund has studied histologic material from 125 autopsies, examining especially the eye, brain, aorta, coronary arteries, and kidneys. In most instances, clinical histories were available and, in some cases, ophthalmoscopic descriptions of retinal vessels had been made. From this data, Lund has derived over 40 graphs or charts to show the degree of correlation of arteriosclerosis of the retinal blood vessels with that of other organs. The incidence and the severity of sclerosis of retinal and cerebral vessels are the most comparable. Renal vessels show the next best correlation with retinal vessel sclerosis, and the aortae show the least. Lund also found that while clinically symptomatic cerebral sclerosis is usually accompanied by changes in the retinal vessels, in senile dementia there was no such association.
The author emphasizes the diagnostic value of the study of retinal blood vessels and stresses their importance in the recognition of cerebral and generalized
Regan EF. Uber den Wert retinaler Gefässveränderungen in der Diagnostik der Arteriosklerose.. Arch Ophthalmol. 1965;74(1):139. doi:10.1001/archopht.1965.00970040141027
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