In connection with an article, "Comparison of Adrenergic Receptors of the Intraocular Muscles in Cat, Rabbit and Monkey," by G. W. H. M. van Alphen, MD, Rudolf Kern, MD, and Sarah L. Robinette, BA, appearing elsewhere in this issue, the editors solicited the following pertinent editorial and bibliography.
A powerful tool for pharmacologic analysis of the response of tissues innervated by postganglionic sympathetic fibers was discovered in 1958. Powell and Slater1 synthesized and studied dichloroisoproterenol (DCI), the 3,4 dichloro analogue of isoproterenol (Isuprel).
Prior to the development of sympathetic blocking agents,2 levarterenol bitartrate, isoproterenol, and epinephrine were generally compared in parallel in any analysis of an exogenously generated response in tissues innervated by postganglionic sympathetic (adrenergic) fibers. Each of these three compounds has different effects, overlapping in some instances, and seemingly opposite in others. Some examples may be cited. Isoproterenol exerts powerful bronchodilation; its companion compounds, little, if
Marvin L. Sears. Adrenergic Receptors. Arch Ophthalmol. 1965;74(2):150–151. doi:10.1001/archopht.1965.00970040152002