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August 1965

Long-Term Treatment With Idoxuridine and Steroids: A Complication in Herpetic Keratitis

Author Affiliations

From the Cornea Service of the Massachusetts Eye and Ear Infirmary. University of Alberta Eye Research Fellow (Dr. Zucker).

Arch Ophthalmol. 1965;74(2):172-174. doi:10.1001/archopht.1965.00970040174009

Idoxuridine (IDU) has been proved effective in the treatment of early epithelial herpetic keratitis.1-3 In cases with stromal involvement moderate doses of topical steroids in conjunction with idoxuridine are usually indicated.4 This combination of drugs has saved many eyes with severe herpetic keratitis or uveitis. In many cases treatment with small doses of idoxuridine and steroid must be maintained over a long period in order to prevent recurrence of the disease. If such a schedule is followed without accompanying antibiotics, there is a risk of secondary bacterial infection developing in the cornea. Four cases are presented to illustrate this point.

Report of Cases 

Case 1.  —A 60-year-old plasterer was seen early in January of 1962. He stated that four weeks previously he got lime in his left eye and was attended by an oculist who prescribed a topical steroid preparation.Examination revealed a markedly injected left eye with