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August 1965

Studies on the Metabolism of the Regenerating Rabbit Lens

Author Affiliations

Rochester, NY
From the Department of Surgery, Division of Ophthalmology, University of Rochester School of Medicine and Dentistry.

Arch Ophthalmol. 1965;74(2):244-247. doi:10.1001/archopht.1965.00970040246023

According to Chanturishvili,1 the possibility of lenticular regeneration was first suggested over 100 years ago. However, it was not until 1956 that Sicharulidze2 reported on the apparently successful regeneration of lens fibers in the rabbit. He employed epidermis from the upper and lower lid commissures of the rabbit embryo and transplanted this tissue into the anterior chamber of the rabbit eye after an extracapsular lens extraction had been performed. Chanturishvili1 essentially corroborated these results with mouse experiments in 1958. In 1959, Stewart and 'Espinase3 also reported that the implantation of the fetal tissue resulted in apparently full regeneration of the rabbit lens approximately ten months after surgery. In all of these studies cytolyzing fetal ectoderm was employed and no significant lens regeneration was observed without this tissue. Recent reports4,5 would indicate that in the rabbit eye a similar degree of lens regeneration can be obtained

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