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August 1965

Movement of Albumin and Dextran Through the Sclera

Author Affiliations

Uppsala, Sweden
From the Institute of Pharmacology, University of Uppsala.

Arch Ophthalmol. 1965;74(2):248-252. doi:10.1001/archopht.1965.00970040250024

Introduction  A previous paper3 reported that labeled albumin injected into the suprachoroid penetrates the sclera through the perivascular spaces and most probably also through other pathways and moves into the conjunctiva where it is then collected by conjunctival lymph vessels.In the present experiments the drainage of albumin from the suprachoroid was studied with an improved technique in animals with an intact anterior chamber and in animals with a low intraocular pressure due to chamber puncture. It was also determined to what extent albumin injected into the suprachoroid can pass into the blood after the cervical lymph vessels have been opened. The routes for colloid drainage through the sclera were studied using red dextran.

Methods  Albino rabbits weighing 1.8 to 2.8 kg were used. Anesthesia was induced by I.V. administration of pentobarbital (30 mg/kg body weight). Additional doses were given if required for the suprachoroidal injection but after this

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