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August 1965


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403 A Smith Ave Chapel Hill, NC

Arch Ophthalmol. 1965;74(2):292. doi:10.1001/archopht.1965.00970040294041

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To the Editor:  The article entitled, "Experimental Diabetic Retinopathy in Dogs" (Arch Ophthal 73:205-210, 1965), by Engerman and Bloodworth, is indeed interesting. They have produced lesions of the retinal capillaries of dogs which are similar to those seen in humans with diabetic retinopathy by treating alloxan- and metasomatotropin-induced diabetic dogs for more than four years with just enough insulin to prevent ketosis and yet allow them to spill 4+ sugar in their urine.They are quite right in concluding from their limited data that "the evidence indicates that diabetic retinopathy is dependent to a lesser extent on the cause of diabetes than on its duration, and is a result of metabolic rather than genetic aberrations of diabetes."However, they have not shown that diabetic retinopathy is produced by an absolute or relative deficiency of insulin and not by complex metabolic changes which are not wholly insulin-dependent: all their animals had

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