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September 1965

Corneal Edema and Intraocular Pressure: I. Animal Experiments

Author Affiliations

From the Corneal Research Unit, Institute of Biological and Medical Sciences, Retina Foundation.

Arch Ophthalmol. 1965;74(3):375-381. doi:10.1001/archopht.1965.00970040377018

The relationship between intraocular pressure, corneal hydration, and transparency has received attention in the past and the subject deserves a review. As early as 1873 Leber1 had found that in freshly enucleated eyes an intraocular pressure of around 200 mm Hg caused bullous epithelial edema within a few hours. He also described the oft-quoted experiment of inducing stromal opacification by squeezing the eye, and the clearing which takes place when pressure is released.

Bullot (1904)2 suspended rabbit eyes, with epithelium removed, in sodium chloride solutions of varying tonicity. The use of hypotonic solutions caused a temporarily increased intraocular pressure and the corneas remained relatively thin and transparent. Conversely, when the eyes were bathed in hypertonic saline solutions, low intraocular pressure and swollen corneas were the result. The author ascribed the different hydrations of the cornea to the level of the intraocular pressure.

Kinsey and Cogan (1942)3 immersed

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